CBstat: A Program for statistical Analysis in Clinical Biochemistry


CBstat Guided Tour

CBstat (Intro)

CBstat (Method comparison)

CBstat (Ref. Interval)

CBstat (Dia. Test)

CBstat (General)




Publications concerning statistical methodology in clinical chemistry:

Linnet K, Boyd JC. Analytical validation of methods With statistical methods. In: Burtis C, Ashwood ER, Bruns D (eds.) Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4.ed. New York: Saunders, 2006, pp. 353-407.

Linnet K. The exponentially weighted moving average (EWMA) rule compared with traditionally used quality control rules. Clin Chem Lab Med 2006; 44: 396-99.

 Linnet K. Estimation of the limit of detection with a bootstrap-derived standard error by a partly non-parametric approach. Application to HPLC drug assays. Clin Chem Lab Med 2005; 43: 394-9.

Linnet K, Kondratovich M. Partly nonparametric approach for determining the limit of detection. Clin Chem 2004; 46: 732-740.

Linnet K. Nonparametric estimation of reference intervals by simple and bootstrap-based procedures. Clin Chem 2000; 46: 867-869.

Linnet K. Necessary sample size for method comparison studies based on regression analysis. Clin Chem 1999; 45: 882-894.

Linnet K. Misleading result of paired t-test in method comparison studies. Clin Chem 1999; 45: 314-315 (letter).

Linnet K. Performance of Deming regression analysis in case of misspecified analytical error ratio in method comparison studies. Clin Chem 1998, 44: 1024-1031.

Linnet K. Evaluation of regression procedures for methods comparisons studies. Clin Chem 1993, 39, 424-432.

Linnet K. Analytical goals for accuracy and precision of plasma creatinine determinations evaluated by reference method measurements. Upsala J Med Sci 1993, 98, 349-54.

Linnet K. Analytical goals for P-Bilirubins. Upsala J Med Sci 1993, 98, 355-8

Linnet K. Mean and variance rules are more powerful or selective than quality control rules based on individual values. Eur J Clin Chem Clin Biochem 1991, 29, 417-424.

Linnet K. Estimation of the linear relationship between the measurements of two methods with proportional errors. Stat Med 1990, 9, 1463-1473.

Linnet K. Assessing diagnostic tests by a strictly proper scoring rule. Stat Med 1989, 8, 609-618.

Linnet K. The between-run component of variation in internal quality control. Clin Chem 1989, 35, 1416-1422.

Linnet K. Minimum detection limits for thyrotropin assays. Clin Chem 1989, 35, 1805 (letter).

Linnet K. Choosing quality control systems to detect maximum medically allowable analytical errors. Clin Chem 1989, 35, 284-288.

Linnet K. Influence of sampling variation and analytical errors on the performance of the multivariate reference region. Meth Inf Med 1988, 27, 37-42.

Linnet K. On the sensitivity of linear discriminant analysis to sampling variation and analytical errors. Comput Biomed Res 1988, 21, 158-168.

Linnet K. Testing normality of transformed data. Appl Statist 1988, 37, 180-186.

Linnet K. A review on the methodology for assessing diagnostic tests. Clin Chem 1988, 34, 1379-1386.

Linnet K. Comparison of quantitative diagnostic tests: Type I error, power, and sample size. Stat Med 1987, 6, 147-158.

Linnet K. Two-stage transformation systems for normalization of reference distributions evaluated. Clin Chem 1987, 33, 381-386.

Linnet K, Brandt E. Assessing diagnostic tests once an optimal cutoff point has been selected. Clin Chem 1986, 32, 1341-1346.

Linnet K. Precision of sensitivity estimations in diagnostic test evaluation. Power functions for comparisons of sensitivities of two tests. Clin Chem 1985, 31, 574-580.